Hyperkalaemia in acute leukaemia: a sign of adrenocortical insufficiency

Exaggerated hyperkalaemia in acute myeloid leukaemia.

Oral lesions presenting as an early sign of acute leukaemia.

To cite: Vourexakis Z. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014205100 DESCRIPTION A middle-aged patient with no major comorbidity presented to the emergency department with severe odynophagia and painful oral lesions of 3 days’ duration, and pronounced fatigue along with unusual recurrent bruising for almost a month. Inspection of the oral cavity (figu...

Oxidative stress and adrenocortical insufficiency

Maintenance of redox balance is essential for normal cellular functions. Any perturbation in this balance due to increased reactive oxygen species (ROS) leads to oxidative stress and may lead to cell dysfunction/damage/death. Mitochondria are responsible for the majority of cellular ROS production secondary to electron leakage as a consequence of respiration. Furthermore, electron leakage by th...

Immunoreactive corticotrophin levels in adrenocortical insufficiency.

Plasma concentrations of immunoreactive corticotrophin (ACTH) have been determined in 14 patients with untreated Addison's disease and in 42 patients with secondary adrenocortical insufficiency. Basal morning plasma ACTH levels were markedly raised in those with Addison's disease but were either in the normal range or undetectable in the group with secondary adrenocortical insufficiency. In the...

Diagnosis and Treatment of Adrenocortical Insufficiency

ONE hundred and three years ago Thomas Addison (Addison, 1855) described the disease which now bears his name. Since his classical description, knowledge of adrenal disorders has widened and increased until it has developed into one of the most exciting and fruitful fields of clinical and biochemical research in the history of medicine. After Addison, many years had to pass before new chemical ...